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KMID : 0363320080290020432
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 2 p.432 ~ p.442
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The Effects of Ssanggang-tang on Rat with Induced Hyperlipidemia
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Lee Jae-Hwi
Lim Seung-Min
An Joung-Jo
Yoo Ho-Ryong
Cho Hyun-Kyoung
Kim Yoon-Sik
Seol In-Chan
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Abstract
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Objective : Ssanggang-tang(SGT) is noted as an effective method to treat hyperlipidemia in China. The main purpose of this study was analysis of the effects of Ssanggang-tang(SGT) on rats induced with caused hyperlipidemia.
Methods : We observed 3 experimental groups: normal, control, and SGT. Rats were provided a normal diet in the normal group, and the other groups were provided a hyperlipidemic diet to induce hyperlipidemia. After 2 weeks, SGT was treated in the SGT group. For 6 weeks, values related to hyperlipidemia were observed in the 3 experimental groups.
Results : SGT decreased some values related to hyperlipidemia like total cholesterol, low density lipoprotein cholesterol(LDL cholesterol), triglyceride, acetocoenzyme A acetyltransferase(ACAT), and 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase). However, it showed no effect on weight change or high density lipoprotein cholesterol(HDL cholesterol).
Conclusion : These results suggest that SGT might be effective in treatment and prevention of hyperlipidemia.
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KEYWORD
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Ssanggang-tang, Hyperlipidemia, Cholesterol
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